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Gene Mutations

2 posts on this thread and the last post was on March 8th, 2009 12:14 PM
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Zuleika - March 7th, 2009 10:11 AM
[Original Post]

After having my first child from a previous marriage (now eleven), I have since had three miscarriages. I took several blood tests to find out what might be the cause. These were the results:

Factor V Leiden single mutation R506Q
MTHFR C677CT two mutations (homozygous)
Prothrombin variant (Factor II), single mutation 20210G]A

My OBGYN told my single mutations had no medical value and put me on 81mg asprin for the mthfr mutation. My question is, after doing research on my own I read that these mutation put together do pose a threat and lack of folic acid and B vitamins play a big role in the mthfr mutation. Also I was not tested for homocysteine levels. I feel that baby asprin alone is not a solution and having all three mutations must be serious. Please help, in desprate need of info.

Thanks Zuleika, Puerto Rico


Lybaum - March 7th, 2009 9:57 PM

Zuleika: After 4 m/c's I was tested and found to have MTHFR. I was put on Lovenox starting day 6 of my cycle. I was also put on a baby aspirin and folgard(vitamin with high dose of vitmin B's and folic acid). Your body breaks down the folic acid so your body isn't absorbing it like it should. I will be 8 wks pg on Monday and maintaining with these meds so far. I do have a friend who also has MTHFR but because she hemorrhaged after a D&C she was only able to take the folgard and is expecting in April. From what I read it is recommended to stay on baby asa and the folgard because it can cause issues with heart disease as you get older. There isn't a lot of information out on MTHFR- What does your OB mean with the mutations have no medical value. I would question his plan just simply with the fact of the 3 m/c's. Hope this helps some. londa, minnesota/US


stefkay - March 8th, 2009 12:14 PM

Zuleika, Actually look at the positive here in that you were actually able to find out that you DO have these mutations. So many women have losses and never get an explanation. I have MTHFR and was also put on Lovenox and had my daughter this past July. I am sorry but you need to find a new dr. Is this a regular OB, a general practitioner or what? Having all of these mutations also complicates it further. Just having both mutations of MTHFR should qualify you for blood thinners during a pregnancy. I was on them and mine is only a single mutation. I strongly believe that a lot of dr's don't know that much about these things yet as it is still fairly new. No, baby aspirin alone is not the answer to your issues. I know you have a child already but I did a lot of research on this and it seems that many women with these mutations have children early on and the mutations become more problematic as they get older. You can and will have a baby just don't waste any time and find a new dr...possible a RE (reproductive endocrinologist) if you can or a fertility specialist who has knowledge of clotting disorders and recurrent pregnancy loss.