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Hi Erin - Congratulations!!! I'm thrilled for you. Your success can give us all hope. Thanks for updating us on where you are. Please keep us posted - it is great to hear about a happy story! And thanks for the links and info.

Erin,Thanks for all your info!! What doses of vitamin B6 and B12 did your specialists recommend?

I do enjoy hearing all of yalls success stories. Also thank you for the good information Erin. Unfortunately I have nothing to report because the receptionist at the Docs office messed up the schedule, so my wife and I will be seeing the doc about our results this upcoming Tuesday. Will keep you all posted.

I was prescribed FOLTX, which is a combined Folic Acid, B6 and B12 supplement. My insurance only covers part of the cost, unfortunately. It contains 2.5 mg folic acid, as opposed to 400 micrograms in over the counter supplements. It is given to anyone who elevated homocystine levels to bring them back down to normal, and now in MTHFR patients so that their homocystine levels don't rise in the first place. My father takes it because although he was never tested for MTHFR (I"m adopted anyway), he did test slightly high for his homocystine levels a few years back. I also take a baby aspirin a day, as back up. The specialist said I could stop it or continue for awhile longer if I wanted. Up to me. You need to stop for a month or two before delivery so you don't bleed too much.

This site shows how much Folic Acid and B vits are in Folgard, Foltx, Folbee and monthly costs. It also shows you how to approximate the dosages with over the counter supplements.

http://www.fvleiden.org/ask/77.html

Erin ~ Thanks so much for posting! I've been having some lows, wondering if I should even conceive again based on the "risks" of having MTHFR. I'm so happy to hear you're having a good pregnancy. I'm also adopted and in some ways, I'm thankful that something "good" came out of my miscarriages since I've never known my medical history. Even tho having MTHFR isn't positive, at least I know. I'm a homogenous MTHFR so both my mother and father gave it to me. It's the only link I have to them. Anyway, please keep us posted. I'm getting my homocysteine tested the week of March 7, and hopefully TTC later in March (if all goes well with the test). ~Cheryl

Erin. Congratulations! It's wonderful news for all of us mthfr gals. Please keep us posted and thanks for all of your helpful info.

Hello. I'm new to this site. I was told recently, after two mc and extensive blood work, tha tI have a MTHRF gene mutation. I found this site and am surprised to see how many women have been dealing with this. My doctor recommended daily aspirin and 400 mcg of folic acid in addition to the prenatal vitamins until I meet with her to discuss whether my levels are within normal range. It's nice to know I"m not alone.

Hello Ladies, I am a little different than you and I am so lucky to have found all of you though. I am 26 years old and am pregnant. I don't want that to be construed as throwing it in your face I am telling you my story. My cousin has had 6 miscarriages and was tested positive for Leiden V Factor. Her mom and another Aunt also were tested for it and found they had it. I told my Dr. about the family history and he immediately had me tested for it. I do have it so I am on injections of heparin. He sent me to a high risk Dr. and that Dr. told me I also have MTHFR. He put me on the folic acid, B-6, B-12, calcium, and aspirin. I told my cousin who has had the miscarriages and she does not know if she was ever tested for it. The specialist scared me big time with the problems associated with MTHFR. My Dr. told me that he will not let me deliver naturally because there is a chance the baby will have a stroke. I am very scared and my heart goes out to each and every one of you. I am very scared. Has anyone ever heard of a stroke for the baby?

Hi Carlie - Congratuations on your pregnancy. I must admit, stroke at delivery is not one I've ever heard it. My specialists seem very relaxed about MTHFR if you are taking the folic acid/b vitamin supplement, your homocystine levels are normal, and you are taking an aspirin a day. I do know another woman who was homozygous for MTHFR and she was on heperin but delivered naturally. There is still a lot to be learne about MTHFR and what it is associated with. It is definitely associated with an increase in blood clots, stroke, etc... but only in those with high homocystine levels. Homocystine levels can be easily managed with folic acid/b vitamin supplements.

Carlie, it was good hearing your story. I want both my parents to get tested for MTHFR since I have it. I don't think they understand the implications it can have on them (since they aren't trying to get pg and all!). I'm still trying to find out the dosage of b6 and b12 I should be taking. What did your dr. recommend? thx!

Mm - I posted that information in a web link above. It tells you what over-the-counter amouns of folic acid and b vitamins you need to approximate Foltx/Folgard. I want to add that although I am delighted to have been diagnosed and to be treated for MTHFR, I did have a completely normal pregnancy without any clue that I had it and without any meds or special supervision. So, although MTHFR can cause issues that need to be watched carefully, it doesn't always. Hope that gives you all some hope. If you are being treated, odds are you will be just fine.

Mm, I am currently taking 4mg of folic acid, 200mg of B-6, 500mcg of B-12, 1000mg of calcium carbonate, and a baby aspirin. I hope that helps.

Hello, (my other info is posted above). Does anyone know what low homocystein levels are from. My regular OB ordered the tests to speed things up since I could not get into a cardiologist until Mar2 and a parinatal Dr until 4/21. I just got the levels back expecting high or even normal and the levels are low. If you have the chromosomal mutations I know high levels of the homocystein are caused by the improper bodily usage of folate. You need more folate and then the levels of homocystein come down. What in the world causes low homocystein levels and is it a problem? Still waiting on parent testing for genetic issues. Mine have got it done but we need my husbands parents tested as well since he has the A and C mutation exactly like I do. They are being sticks in the mud and dragging their feet. I have my cardiologist appt on Thursday. I'll keep you posted. K

I would not worry and count yourself lucky. Low homocystine levels are not a problem. You might have an excellent diet (do you eat fortified cereals, green veggies?). OR, according to some studies I have read, some people, including homozygotes, just don't appear to be affected by MTHFR issues, or not always. Sometimes age is a contributing factor. I would just take precautionary measures and discuss with your doctor. Low homocystein is good!

Hi. I am wondering if anyone will share their thoughts with me. I had a early m/c when I was 24..then a healthy normal pregnacy at 25 and delivered a healthy, full -term baby boy. I am now 27 and experienced another early m/c with a twin pregnancy. My OB ran some tests and I came back + for a MTHFR mutation on one alle. He prescribed a folic acid supplement....Do I need the baby aspirin and other B vitiam supplements? Can anybody offer knowledge on what they know about one mutation on one alle. What does that mean for future pregnancies?