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Hi. I am wondering if anyone will share their thoughts with me. I had a early m/c when I was 24..then a healthy normal pregnacy at 25 and delivered a healthy, full -term baby boy. I am now 27 and experienced another early m/c with a twin pregnancy. My OB ran some tests and I came back + for a MTHFR mutation on one alle. He prescribed a folic acid supplement....Do I need the baby aspirin and other B vitiam supplements? Can anybody offer knowledge on what they know about one mutation on one alle. What does that mean for future pregnancies?

If you only have one mutation on one allele (heterozygous) it is unlikely that MTHFR is causing your problem, although some studies have shown that heterozygotes can sometimes have higher homocysteine levels. Have the doctor check your homocystein levels, but don't rule out other possibilities for the mc's just yet.

Thanks for the info...just peeling through what I can find on the web...it is somewhat confusing. Sorry for the misspelling. Any suggestions on where I can go to read more about MTHFR? So is my OB just being proactive with the folic acid supplement?...Thanks again!

I just checked the dosage on my supplement....it is only 1 MG compared to the 5 MG I see most people posting. Do you think it should be 5 MG or not since you don't think the MTHFR is the cause of the m/cs? I am interested in any thoughts. Thanks!

Hi everyone...I am so happy to find this forum. I have had a tough history as many of you have experienced as well. I have a 3 year old little boy..and through that pregnancy everything was great. I delivered him C-section and was pregnant 10 months later. Unfortunately, that endedwith an ectopic pregnancy. It was a disaster becuase it had fallen out of my tube and attached to the ovary and bowel. Needless tosay I needed laproscopic surgery and a shot if metholtrexate. The D and E did not work bc there was nothing in my uterus. Following that, I waited about 7 months and got pregnant again. this time and for 3 consecuove pregnancies, I miscarried. All seemed to have different reasons. 1- blighted ovem, 1- no reason 3- triploidy. The last one was followed by fertility. Just recently, I switched to a new fertility doctor and had tons and tons of bloodwork done as well as a hysteroscopy. Ends up that I did have scar tissue in my uterus which was removed and found out that I have MTHFR also. The doctor said that it is compund heterozygous (C667T and A1298C). My homocysteine levels are normal. I have been proactively taking additional folic acid, my regular prenatal (Vitafol), baby aspirin, and Vitamin B compound. The doctor suggested that I continue this and once pregnancy is confirmed begin levonox shots as a precautionary due to my history. He said through the first trimester. I am so confused and scared. At one point, I thought I should just forget everything and adopt. We really want another child. I have to also say that I was worried about chromosomal abnormalities, tobal defects, etc. Is there reason for concern? I work in special education and can't help but think and wonder about that. What does anyone think?

Well I told yall I'd keep in touch with what happend with my wife and I after our appointment to discuss our results. I have to say I was really disappointed with the information we did or did not receive. Honestly, thanks to you ladies, I feel we were more prepared with information about MTHFR than the doc was. Long story short, he didn't recommend any folic or b medicines or even baby aspirin. He basically just said bad luck and keep trying. So I had to bring up with him that I've been on this forum and have heard that the folic, and b vitamins could be of help. He agreed that it might and said we could try it if we wanted. That was about it. So we went and bought all the supplaments ourselves and had to talk to the pharmacist at Target to find out more about dosages. Out of curiousity...do any of yall have a more informed doctor on MTHFR that live in the Northern Virginia area? I'm thinking about getting a second opinion. Thanks.

Hi Nate~ My name is Amy & I have posted a few entries about. To sum up quickly, I have had 2 mc's and have the A1298C mutation. I am seeing Drs. Lantz and Sweeney at Anne Arundel Medical Center in Annapolis, and my husband and I are pretty happy with them so far. Also, I have some info. on the Genetics and IVF Institute in Fairfax; I have heard that they are pretty good if you feel like you want to go that route (our doctors say that we don't quite need to try that yet). Also, one of my friends told me that Shady Grove Fertility in Rockville is pretty good. I hope that this helps!!

Hi Nate,

I did go to Genetics and IVF just for a consult on MTHFR. They were GREAT! I'm planning on trying again without help (except the vitamins that everyone else has mentioned). They do give you a complete analysis of the mutation and how to handle it for pregnancy and for the rest of your life.

Hi all. I just got good news - My homocysteine levels are normal. This has been the barometer for me on whether we try this month. Anyone else TTCing around the end of March??

I just came across this site while searching about MTHFR. I was informed yesterday that I have both c677t and a1298c. I am about 7 weeks pregnant.

Background....I have a 26 mo and a 13 mo. I had the start of preeclampsia with my first and had an emergency induction, but I was 38 weeks, so the baby was ready. My blood pressure did not go back to normal right away, as in most cases, but was high for several weeks after the birth. No medical reason why. No problems with my second child, except that she was footling breech and had to be delivered via csec. I did have a pregnancy before my first child was born that ended at about 7 weeks in miscarriage.

In the meantime, my middle sister, who had her baby about a year before my oldest had a miscarriage. Her doctor decided to run a bunch of tests and found that she had the MTHFR c677t mutation. They sent her to a specialist who put her on Lovenox for her entire pregnancy. She gave birth to her baby girl a couple weeks ago with no complications. Interestingly, with her first pregnancy, she was on bedrest from 4 mos on for high blood pressure and when baby was born (she made it almost full-term) the placenta was about 1/3 of the size it should have been and her amniotic fluid was barely a trickle. We were lucky that she was not harmed.

I also have another sister who was tested and she also has the MTHFR c677t. She had a normal pregnancy and birth with her daughter as well, though her daughter had a minor birth defect. When she was born, a piece of skin just under her chin was actually attached to her chest. Like if you bend your head forward and connect it. Fortunately they were able to just cut the piece and sewed it up and she was fine (there was some concern that there could have been important veins or tissues inside the connection, but there was not).

So, interesting information. Is this disorder the cause of these strange episodes, or were they caused by something else?

What people need to remember is that DNA has only been known about for 10 years or so now and researchers have only BEGUN to understand all the facets.

It is possible that this mutation is the cause of so many problems. It is also possible that it has nothing to do with it. I figure that if there is a possibility that my child or I will be harmed and I can help that not to happen, I will do everything I can. For those out there who doubt the science or even the theories, I say believe what you will, but allow others to believe what they will.

Ya know, my mom smoked while she was pregnant with my sisters and I and we are fine. That is not a good enough reason for me...I quit to have babies (after 10 years of smoking). If there is ANY chance that smoking could harm my child, I will not risk it. Which is why I will take medication, as recommended by my doctor. Because what if my child is born with a neural tube defect and I refused the medication. I will always blame myself for not doing everything I could to avoid something like that..

Anyway, just wanted to share my story and my opinion.

Heather

Dear.Want1more. I will be trying to conceive at the end of March. We tried on our own this month as the fertility Dr's weren't going to be in on Wed when I would have been ovulating to do the insemenation. I doubt that I will get pregnant as it has been a long time since we got pregnant on our own and that ended in a m/c. I have homo...mthfr with an elevated homocystine level. I'm taking 4mg of Folic Acid 25mg of B6, 500mcg of B12 and baby aspirin. We are hoping for the best but the last IUI failed. Good luck to you and keep posting.

Hi all!! I have 2 children(15 and 2 3/4), i've had 3 miscarriages in a year and a half(the last one just last week confirmed two days ago. I also found out that I have MTHFR. I only have the single one, but my doctor says he doesn't think this is what is causing my m/c's. he said I can start Flolic, B6 and B12 right away. The last m/c i was on progesterone supp. and baby aspirin and m/c anyway. Each m/c was at week 4, 4.4 and 4.6. I'm at a loss and can't understand why this(MTHFR) couln't be causing this and that this just happens becuase it wasn't meant to be?

Have you had your progesterone levels checked? Ask you doctor if you haven't. You need blood taken on day 21 of your cycle two months running.

Dear Want1More...I hope that my wife and I will be starting at the end of this month or beginning of next. Basically since we aren't taking any more tests before we try again, we're gonna let the folic/b6/b12 do its thing for about a month, pray and try again. Will keep yall posted.

Nate and Gigismith ~ I should have signed my name since my screen name doesn't give it away. It's Cheryl. I'm TTC #3 after 2 m/cs. I look forward to hearing your updates. I'm hoping to ovulate around March 24. Just got the go ahead from my ob today to go for it. Take care.

Hi my name is Trisch. I'm 29 years old & I have had 9 pregnancies. I have 3 healthy children. I had 1 miss in between my 2nd & thrd the other 6 were back to back 2004-06. in Nov 05 I saw a specialist. He did a series of bloodwork & diagnosed me with the MTHFR mutation. I now take 2 MG folic acid & 1 baby asprin daily. I am desperately trying to get pregnant again.It has now been 7 months since my last miss & nothing.I'm sure all of you know what I'm going through. I am looking for a little support. I am so glad i found this site.Looking forward to hearing from all of you.