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I just bought them today for my daughter who is constipated. It says to give it at bedtime, but I've heard about kids reacting to different laxatives like this in different ways and what if she got really bad stomach aches or cramps during the night and then was up all night. So then I thought I'd just give them to her in the morning but then I realized if it said to give it to her at bedtime there must be a reason for it... does anyone know if there is? Maybe it doesn't work well during the day when she's eating and stuff so maybe she needs to have it at bedtime so it can work overnight? I know, I'm paranoid! haha