CPC S

1 Replies
annab - October 28

I'm 36 and this is my first pregnancy and went for my 2nd trimester ultrasound (week 20) and they found 3 CPC's and I'm sorta freaking out. Two of them are 3mm and one of them on the left side is 9mm otherwise everything on the ultrasound looked good. They advised me to do think about an amnio but I'm really scared that it could lead to a miscarriage so don't think I could live with that. They scheduled me for another ultrasound in 5 weeks to see if the CPC's shrank but I've been reading that they tend to shrink most of the time anyways and they are still a soft marker regardless if they shrink or not for abnormalities (especially trisomy 18). I know the chances of abnormalities are low but the chances of having CPC's is also low (1%) so I'm getting a bit paranoid if my baby is abnormal. Reading this message board sure helps but now I'm going a little nuts thinking about this everyday and wondering about the amnio.

 

Tory1980 - October 28

I am sorry to ehar that your little one may not be well. I would say you need to ask yourself one question - should an amnio come back also positive would you abort or take your chances that you are in the percentage that all will be well? As for the amnio, if you aren't comfortable with doing it, don't. Granted 5 weeks is a long time away but maybe waiting for the scan would be your best bet and if the markers are still present then consider further testing. Why are they making you wait for 5weeks? I did find this information though and by what I can figure there is a low chance of anything being wrong since everything else has come back clear. ------------ CPCs are seen in about 1% to 2.5 % of normal pregnancies as an isolated finding, and they are usually of no pathologic significance when isolated. CPCs can be single or multiple, unilateral, or bilateral. Bronsteen and colleagues[54] studied 49,435 fetuses between 16 and 25 menstrual weeks; CPCs were identified in 1209 (2.3%), with 1060 cases of isolated CPC. The authors found that no fetus with an isolated CPC had trisomy 18. During the study period, 50 cases of trisomy 18 were identified between 16 and 25 menstrual weeks. CPCs were detected in half of these fetuses. They concluded that prenatal sonographic identification of CPCs warrants an extended anatomic survey that includes the fetal hands. If the fetal examination is otherwise unremarkable, then the risk for trisomy 18 is low. The probability of a chromosomal abnormality is high when CPCs are a__sociated with any other antenatally detected anomaly, indicating a clear need to offer amniocentesis. Gupta and colleagues[60] studied a large unselected population and concluded that the predictive value of CPCs is much lower when no other anomalies are detected. They also concluded that risk did not seem to be related to whether or not cyst size diminishes as gestation progresses, whether the cysts were unilateral or bilateral, or whether they were small or large (60% to 80% < 10 mm). It is probably advisable to regard CPCs as an indication for detailed ultrasound a__sessment, rather than invasive testing.

 

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