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RYC09 - I was subscribed 200mg Prometrium 1x/day as well by my doctor for low progesterone in early pregnancy. He wanted me to take it orally, but I'd read lots of places (including in these posts!) that it's more effective if taken vaginally, so that's what I did. I asked my doctor first if I had to get a different prescription and he said no -- the prometrium pill could be swallowed or inserted vaginally as a suppository. It seems weird to shove a pill up your vaginal canal rather than swallowing it, but that's what I did and it WORKED LIKE A CHARM! I'm now 29 weeks alon and in my last trimester; my little guy (knock on wood) is doing just fine. Good luck!

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