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Your lupron shot goes about an inch below your belly button and you have to alternate sides. So it pretty much has to stay in one are, but the needles are really small, like diabetic needles so its not so bad. I did bruise a couple of times, but never had pain from them. Right, flatten the skin and it didn't matter which way you flatten it, it just helped the needle go in smoother. I don't know about you, but i had a little fat right there, so that kind of helped. I am not sure what a PIO shot is. Is is progesterone? I was on progesterone shots from the day of ER until I hit 10 1/2 weeks pregnant. I can tell you about those if that is what you were talking about. Sorry I am kind of slow with the lingo. I still haven't felt anything. Doc says I should in the next week or so. I thought I had once or twice, but it was probably just gas. I am starting to get a small outie belly button, which I am not to excited about that. My husband thinks its funny. But that is something I can't really do much about, oh well.

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