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My info is not opinion or hearsay. It is from published research on this very topic. Several studies have compared rates of multiples on various drugs: injectable gonadotropins, clomid alone, clomid+met, metformin alone. Injects carry the highest rates of twinning, followed by clomid alone. A clomid+metformin combination is next down on the list, while metformin alone carries the lowest chances of twinning. So, while clomid+met has higher chances than a natural/unmedicated cycle, having the met makes the odds thankfully lower than taking clomid alone.

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