Clomid Metformin Chance Of Twins

37 Replies
MiaBlaze - December 24

Can anyone tell me if Clomid plus Metformin increases or decreases your chance of multiples? I just want to have a baby-- no preferrence here, but would like some information! I've heard conflicting reports! So- multiple moms and singleton moms- please reply! (Submitting question to different categories).


yetanothertripletmom - December 24

Metformin, alone or in combination with clomid, will not increase your chance of multiples. Clomid can increase your chances. Good luck!


Melissa - December 25

I took clomid alone and was not able to concieve until it was paired with metformin. I now have a daughter who will be 3 in Feb. and 3 month old boy/girl twins. Good luck!


MiaBlaze - December 26

yetanothertripletmom-- I'm not sure I understand your answer. Perhaps I should clarify-- I've heard that Clomid alone increases your chances, but adding Metformin DECREASES your chances (of multiples). Have you heard of this? Also, Melissa, did you conceive both times with the combination? Please share!!! Thanks, ladies!


yetanothertripletmom - December 27

It sure didn't decrease my chance of multiples! LOL. Clomid and metformin do completely separate things. Met works on your endocrine system to even out blood sugar. Excess blood sugar CAN (but not always) cause blood restrictions in the uterus resulting in no implantation of the embryo or a miscarriage. It will not in any way affect the amount of eggs. I'm not sure what your aim is in taking both, maybe your doctor can clear up any questions or concerns you. Good luck.


Melissa - December 28

Yes, we conceived actually 3 times with the combo of metformin and clomid (second one ended in a miscarriage around 6 weeks). I was put on both because it can aid in ovulation for those who have PCOS ( I don't ovulate at all on my own).


MiaBlaze - December 28

Thanks for your responses. I don't have a preference, as explained, but bottom line: I want a healthy pregnancy and healthy baby as the result-- one, two, three, twelve-- whatever God blesses me with. I was told by a friend that Clomid causes hyper-ovulation (as confirmed by my ob/gyn) but I've heard (through a friend) that the Metformin will limit the chance of multiples (not sure how). I'm going to ask my doc at the next appt, but wanted to ask ahead of time from those with experience-- hope that's alright. Melissa, I'm a PCOS'er, as well. Also, I have astronomically high testosterone numbers, causing the lack of O as well as the blood sugar surge. Either way, I've already learned that this whole fertility drug thing is a c___p-shoot at best. I'm convinced I'd have a better shot at guessing my odds in Vegas than figuring out if I'll be pregnant this month or next with one or more babies! Any more advice? I could use it-- mostly to calm my nerves, quite frankly. This PCOS thing and constant testing and constant examinations and... this is a lonely place.


yetanothertripletmom - December 29

I have PCOS too. What a nasty disease, huh? Metformin won't in any way decrease your odds for multiples, but will increase your odds of a live birth.


belindalou - July 8

i am not sure aboutthe two together but would also like to know have 18month old twin boys as a result of clomid dr has decided to put me on metformin so i can try to have another baby does anyone know if metformin alone increases the chance of twins


belindalou - July 8

i took clomid and got pregnant with twins so i know that clomid does increase the risk on its own its about a one in twenty chance while your taking clomid to have multiples im no sure about metformin but i would love to know as i have just been put on it i am trying to get pregnant again.


kelsmi - August 18

I was just diagnosed with PCOS last week. My husband and I really want to have a child and are heartbroken over this, because I don't ovulate at all. I'm beginning all of the check-ups and will talk to my Dr. soon about treatment. Anyone know chances of pregnancy with PCOS? I'm 29 and in really good health (weight wise, etc...). This is such a scary thing!


bump - August 27



CLOMID USER - August 29



BellasMum - March 7

I two have PCOS. I was Diagnosed with it after my freshman year of college in 2001. I had to see a Endo specialist in Maine Medical for several years because my hormones were out of wack. So I was lucky to know about this syndrome before my husband and I started trying for a baby. We got married in 2004 and started trying for baby 1 in 2005 I was put on Metformin with Femara. It worked and we got our daughter. Now she is 2 and we are trying our rounds again. This time Im on Metformin with Clomid (nothing so far, of what I know of). But I would love to have twins. Its in my blood. My mom's a twin and my sister had twins. (My husband's brother and sister are twins as well so it would be a neat addition, although I know it doesnt run on the man's side.) Good luck everyone. *~*~*~*~*~*~ Baby Dust!!~ *~*~*~*~*~*


Lmanis - May 9

Actually I am currently taking Metformin and now currently taking Clomid and my Doc told me that the change of twins is much higher than just using clomid, but i have PCOS so i have to take both...well good luck to you hope you have a healthy baby


Queen_Wench - May 20

My info is not opinion or hearsay. It is from published research on this very topic. Several studies have compared rates of multiples on various drugs: injectable gonadotropins, clomid alone, clomid+met, metformin alone. Injects carry the highest rates of twinning, followed by clomid alone. A clomid+metformin combination is next down on the list, while metformin alone carries the lowest chances of twinning. So, while clomid+met has higher chances than a natural/unmedicated cycle, having the met makes the odds thankfully lower than taking clomid alone.


Teddyfinch - May 21

from what my doctor told me that she was told at a conference for clomid and metformin was that taking both as opposed to taking clomid alone has the same end results.



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